Episode #1050

News Items

        Quickie with Steve

        https://arxiv.org/abs/2507.13461

        Questions and Emails

        Hi Steve and team, I’m probably not the only one to point out that there are many elemental drugs apart from Li. While many indications are for replacement in physiological deficiency, for example Fe2/3+, these have pharmacodynamic properties used to treat a distinct disorder: Mg2+ in eclampsia, cardiac rhythm disturbances such as VT/“Tousades de Pointe”, hypertension, asthma. Ca2+ in haemorrhage and massive transfusion (granted that it is counteracting the citrate effect from RBC infusion), hyperkalaemia and hypercalcaemia. Pt in chemotherapy. Arsenic is also used in chemo. Au in rheumatoid arthritis, granted is now rarely used. Ph in bowel prep for colonoscopy. Ag in burns as antimicrobial, and as cautery agent. Iodine in thyroid disease, for radioactive ablation or protection in radiation exposure. Others that are mainly used for their properties as a salt: Na, K, Se, Bi, Sb, Zn. Hope this provides some additional information for listeners. I use many in my work as an anaesthetist (anaesthesiologist in your parlance). Kind Regards Simon.

        Science or Fiction

        Skeptical Quote of the Week.

        ‘The human understanding is unquiet; it cannot stop or rest, and still presses onward, but in vain. Therefore it is that we cannot conceive of any end or limit to the world, but always as of necessity it occurs to us that there is something beyond.’ Francis Bacon